化学合成；材料科学。
2,2'-联吡啶-4,4'-二甲酸为羧酸类衍生物，可用作医药中间体。
合成路线 1（1. 合成：6813-38-3）
产率：98%
合成条件：at 65℃; for 6 h;
实验步骤：将1.0g的4,4-二甲基-2,2-联吡啶（5.4mmol）加入到反应烧瓶中，缓慢滴加18mL浓硫酸并搅拌，该过程大量加热直至溶液冷却至室温 然后加入重铬酸钾3.3g（11.3mmol），然后溶液变为深绿色，然后在65℃反应6小时。 反应完成并冷却至室温，反应物加入1000mL水中，此时产生大量白色絮状沉淀，抽滤，然后用水和甲醇洗涤，滤液呈白色沉淀澄清。 然后在真空烘箱中于60±18h干燥，产率98％
参考文献：
- [1] Chemical Communications, 2010, vol. 46, # 13, p. 2197 - 2199 [2] Transition Metal Chemistry, 2011, vol. 36, # 8, p. 897 - 900 [3] Patent: CN107417737, 2017, A. Location in patent: Paragraph 0051-0054 [4] Helvetica Chimica Acta, 2018, vol. 101, # 5, [5] Chemical Communications, 2006, # 1, p. 85 - 87 [6] Molecular Crystals and Liquid Crystals, 2003, vol. 395, p. [325]/155-[335]/165 [7] Patent: CN104892503, 2017, B. Location in patent: Paragraph 0029-0031 [8] Journal of the Chinese Chemical Society, 2012, vol. 59, # 9, p. 1053 - 1057 [9] European Journal of Inorganic Chemistry, 2015, vol. 2015, # 29, p. 4878 - 4884 [10] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2016, vol. 165, p. 150 - 154 [11] Synthetic Communications, 1995, vol. 25, # 24, p. 4093 - 4097 [12] Chemistry - A European Journal, 2010, vol. 16, # 1, p. 100 - 103 [13] RSC Advances, 2016, vol. 6, # 52, p. 46487 - 46494 [14] Frontiers of Chemistry in China, 2010, vol. 5, # 2, p. 171 - 177 [15] Journal of the American Chemical Society, 2012, vol. 134, # 2, p. 968 - 978 [16] ChemPlusChem, 2014, vol. 79, # 7, p. 936 - 950 [17] Chemical Communications, 2015, vol. 51, # 27, p. 5840 - 5843 [18] Chemical Communications, 2016, vol. 52, # 46, p. 7398 - 7401 [19] Chemistry - A European Journal, 2017, vol. 23, # 72, p. 18239 - 18251 [20] Tetrahedron Letters, 1990, vol. 31, # 35, p. 5069 - 5072 [21] Journal of the American Chemical Society, 2006, vol. 128, # 25, p. 8234 - 8245 [22] Journal of Materials Chemistry A, 2014, vol. 2, # 34, p. 14228 - 14235 [23] Inorganic Chemistry, 2017, vol. 56, # 1, p. 252 - 260 [24] New Journal of Chemistry, 2017, vol. 41, # 14, p. 6272 - 6277 [25] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 31, p. 3690 - 3697 [26] Tetrahedron Letters, 2002, vol. 43, # 10, p. 1807 - 1811 [27] Journal of Organic Chemistry, 2006, vol. 71, # 1, p. 315 - 319 [28] Green Chemistry, 2010, vol. 12, # 3, p. 400 - 406 [29] European Journal of Inorganic Chemistry, 2008, # 21, p. 3310 - 3319 [30] Tetrahedron Letters, 2010, vol. 51, # 47, p. 6161 - 6165 [31] Synlett, 2013, vol. 24, # 6, p. 765 - 769 [32] ChemBioChem, 2017, vol. 18, # 2, p. 223 - 231 [33] Chemical Communications, 2015, vol. 51, # 53, p. 10746 - 10749 [34] Tetrahedron, 2014, vol. 70, # 36, p. 6271 - 6275 [35] Journal of Polymer Science, Part A: Polymer Chemistry, 2010, vol. 48, # 2, p. 366 - 372 [36] Patent: US2005/112077, 2005, A1. Location in patent: Page/Page column 3; 4 [37] Journal of Organic Chemistry, 2002, vol. 67, # 17, p. 5901 - 5906 [38] Journal of the American Chemical Society, 2010, vol. 132, # 19, p. 6696 - 6709 [39] Tetrahedron Letters, 2011, vol. 52, # 9, p. 995 - 998 [40] Journal of Physical Chemistry B, 1997, vol. 101, # 38, p. 7494 - 7504 [41] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 163 - 165 [42] Journal of the American Chemical Society, 2007, vol. 129, # 18, p. 5919 - 5925 [43] Tetrahedron Asymmetry, 2013, vol. 24, # 8, p. 515 - 525 [44] Polyhedron, 2016, vol. 114, p. 360 - 369 [45] Langmuir, 2012, vol. 28, # 11, p. 5023 - 5030 [46] Advanced Synthesis and Catalysis, 2003, vol. 345, # 4, p. 497 - 505 [47] Journal of the American Chemical Society, 1977, vol. 99, p. 4947 - 4954 [48] Journal of the American Chemical Society, 1946, vol. 68, p. 2574,2576 [49] Journal of the American Chemical Society, 1958, vol. 80, p. 2745,2747 [50] Journal of the American Chemical Society, 1982, vol. 104, # 26, p. 7519 - 7526 [51] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1985, p. 2247 - 2262 [52] Journal of Organic Chemistry, 1992, vol. 57, # 11, p. 3046 - 3051 [53] Journal of Organometallic Chemistry, 1988, vol. 355, p. 193 - 196 [54] Tetrahedron, 1995, vol. 51, # 2, p. 389 - 400 [55] Tetrahedron Letters, 1997, vol. 38, # 25, p. 4389 - 4392 [56] Analytical Chemistry, 2000, vol. 72, # 14, p. 3245 - 3252 [57] Chemistry - A European Journal, 2006, vol. 12, # 26, p. 6738 - 6747 [58] Dalton Transactions, 2008, # 28, p. 3701 - 3708 [59] European Journal of Inorganic Chemistry, 2009, # 9, p. 1256 - 1267 [60] Catalysis Letters, 2010, vol. 135, # 3-4, p. 256 - 262 [61] Journal of the Indian Chemical Society, 2010, vol. 87, # 3, p. 309 - 316 [62] Journal of the American Chemical Society, 2011, vol. 133, # 35, p. 13957 - 13966 [63] Journal of Chemical Sciences, 2011, vol. 123, # 1, p. 37 - 46 [64] Organometallics, 2011, vol. 30, # 24, p. 6572 - 6586 [65] Journal of the American Chemical Society, 2012, vol. 134, # 17, p. 7488 - 7496 [66] Journal of Materials Chemistry A, 2013, vol. 1, # 10, p. 3463 - 3470 [67] Angewandte Chemie - International Edition, 2013, vol. 52, # 38, p. 9956 - 9960 [68] Angew. Chem., 2013, [69] Journal of Catalysis, 2014, vol. 309, p. 21 - 32 [70] Inorganica Chimica Acta, 2014, vol. 414, p. 145 - 152 [71] Catalysis Today, 2014, vol. 225, p. 149 - 157 [72] Inorganica Chimica Acta, 2014, vol. 415, p. 22 - 30 [73] Green Chemistry, 2014, vol. 16, # 9, p. 4179 - 4189 [74] Molecular Crystals and Liquid Crystals, 2015, vol. 607, # 1, p. 250 - 263 [75] Advanced Synthesis and Catalysis, 2015, vol. 357, # 14-15, p. 3127 - 3140 [76] Inorganic Chemistry, 2015, vol. 54, # 21, p. 10214 - 10223 [77] Dalton Transactions, 2015, vol. 44, # 12, p. 5577 - 5586 [78] Patent: CN105793241, 2016, A. Location in patent: Paragraph 0127; 0159 [79] Patent: KR2015/125064, 2015, A [80] Journal of Materials Chemistry C, 2016, vol. 4, # 34, p. 8061 - 8069 [81] Dalton Transactions, 2017, vol. 46, # 23, p. 7421 - 7433 [82] Dalton Transactions, 2017, vol. 46, # 30, p. 10029 - 10036 [83] Patent: CN106939025, 2017, A. Location in patent: Paragraph 0084; 0087-0088 [84] Patent: CN106188151, 2016, A. Location in patent: Paragraph 0023; 0025; 0027 [85] New Journal of Chemistry, 2018, vol. 42, # 4, p. 2979 - 2988
