- 制备
1-溴甲基萘是一种化学物质，其可由1-甲基萘经N-溴代琥珀酰亚胺(NBS)光溴化反应制得。
- 化学性质
白色固体粉末。
未明确提及具体应用领域
合成路线 1（1. 合成：3163-27-7）
产率：99%
合成条件：With ethyl 2,2-dibromoacetoacetate; triphenylphosphine In dichloromethane at 20℃; for 0.50 h;
实验步骤：通用方法：在环境温度下，将α，α-二乙酰乙酸乙酯2a（0.41mmol，1.2当量），醇1a-1s（0.34mmol，1.0当量）和Ph3P（0.68mmol，2.0当量）加入空气中的3mL DCE中。 在室温下搅拌适当的时间（通过TLC监测）后，通过加入H 2 O（3mL）淬灭反应，然后用乙酸乙酯（3×3mL）萃取。 将合并的有机层用盐水洗涤，用Na 2 SO 4干燥并浓缩。 通过硅胶柱色谱法纯化粗产物，用石油醚或石油醚和乙酸乙酯的混合物作为洗脱剂，得到相应的产物3a-3s。
参考文献：
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合成路线 2（3. 合成：3163-27-7）
产率：80%
合成条件：With tribromo-isocyanuric acid In ethyl acetate for 6 h; Reflux; Green chemistry
实验步骤：通用程序：将芳烃（2.0mmol）和TBCA（0.25g，0.68mmol）的EtOAc（20mL）溶液在搅拌下回流6小时。 在反应结束时，然后通过过滤分离沉淀的氰尿酸，并将滤液在减压下蒸发至干。 将残余物通过短色谱柱（SiO 2，用15：1己烷 - 乙酸乙酯洗脱），得到纯化的产物。
参考文献：
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