化学合成。
化学合成
合成路线 1（1. 合成：20870-79-5）
产率：98%
合成条件：at -15℃; for 0.50 h;
实验步骤：5-硝基 - 羟吲哚的制备在-15℃下向羟吲哚（26g）在100mL浓硫酸中的溶液中滴加发烟硝酸（8.4mL）。 小心注意将反应温度保持在-15℃。加完后，将反应物搅拌30分钟，然后倒入冰水中。 形成黄色沉淀，通过过滤分离，得到34克（98％）5-硝基羟吲哚。
参考文献：
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合成路线 2（2. 合成：20870-79-5）
产率：81%
合成条件：With 1-fluoro-1,2-phenyliodohydrin-3-(1H)-one In 1,4-dioxane; water at 140℃; for 5 h;
实验步骤：在室温下向0.4mL反应管中加入0.4mL 1,4-二恶烷。再加2mL水，搅拌并混合。称取1-氟-1,2-苯基碘醇-3-（1H） - 酮（175mg， 将0.66mmol）加入到反应管中并搅拌1分钟。将反应管置于140℃油浴中，加入5-硝基吲哚（97mg，0.6mmol），加入内置冷凝器并进行反应 在140℃的油浴中保持5小时.TLC点板显示原料反应完成，将反应管从油浴中取出，冷却至室温，并通过加入10mL饱和碳酸氢钠淬灭。 用乙酸乙酯（20mL）萃取。蒸汽浓缩有机层，柱色谱法得到粉末状固体5-硝基取代的2-茚满酮86mg，收率81％。
参考文献：
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