(3-溴丙氧基)-叔丁基二甲基硅烷是一种制备哌啶酰羰基磺酸盐的试剂，作为一种新型的抗高脂血症药物，通过接头蛋白常染色体隐性高胆固醇血症上调ldl受体。
医药
合成路线 1（1. 合成：89031-84-5）
产率：93%
合成条件：at 20℃; for 3 h; Inert atmosphere
实验步骤：实施例C：3-（3-（2,5-二氧代-4-（3,4,5-三甲氧基苯基）-2,5-二氢-1H-吡咯-3-基）-1H-吲哚-1-基） 2-氨基-4-甲基戊酸丙酯3-溴丙氧基 - 叔丁基二甲基硅烷Galka等人的改进方法。 （J.Lab.Comp.Rad.2005,48（11）：797-809）用于制备标题化合物。 将3-溴丙醇（39.1毫摩尔; 5.43克），叔丁基二甲基甲硅烷基氯（43.2毫摩尔; 6.47克）和咪唑（46.7毫摩尔; 3.20克）的混合物在室温下在惰性气体下搅拌3小时。 将反应用水淬灭，用二乙醚萃取，将有机层用MgSO 4干燥，过滤并浓缩。 通过柱色谱（PE）实现纯化，得到标题化合物（36.4毫摩尔; 93％）。 1H NMR（300MHz，CDCl3）3.73（t; 3J = 5.7Hz; 2H; CH2O）; 3.51（t; 3J = 6.4Hz; 2H; CH2Br）; 2.02（q; 3J = 5.7Hz; 3J = 6.4Hz; 2H; CH2CH2CH2）; 0.89（s; 9H; C（CH3）3）; 0.06（s; 6H; 2xCH3）。
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合成路线 2（2. 合成：89031-84-5）
产率：92%
合成条件：With 1H-imidazole In dichloromethane at 20℃; for 0.17 h; Cooling with ice
实验步骤：将3-溴丙醇（4.14g，30mmol）加入到DCM（50mL）中，加入咪唑（2.5g，30mmol），在冰下搅拌10分钟，加入TBDMS（4.5g，30mmol）并且 在室温下继续反应。 第二天，DCM（50mL）（30mL X3），经无水硫酸镁干燥并浓缩，得到7g无色油，产率92％。
参考文献：
- [1] Patent: CN107098886, 2017, A. Location in patent: Paragraph 0501; 0502
