3964-56-5 2-氯-4-溴苯酚

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合成路线 3（3. 合成：3964-56-5）

产率：13 %Chromat. 合成条件：With N-Bromosuccinimide In acetonitrile at 20℃; for 2 h; 实验步骤：通用方法：反应条件：将硫脲（5.1mol％，2mg，0.026mmol）加入到含有NBS（1.15当量，104.4mg，0.587mmol）的乙腈溶液（10mL）中。将苯甲醚（56.3mg，0.51mmol）立即加入到得到的搅拌溶液中，并在室温下搅拌10分钟。通过加入10％Na 2 S 2 O 3水溶液（10mL）淬灭反应，并用乙酸乙酯（70mL）萃取。然后用另外的10％Na 2 S 2 O 3（2×10mL）洗涤有机溶液，接着用去离子水（3×15mL）和盐水（2×10mL）洗涤。然后将有机溶液用无水Na 2 SO 4干燥并真空蒸发溶剂。使用2mm厚的硅胶60GF254涂覆的板（5％CH 2 Cl 2 /己烷）通过离心薄层色谱分离每个反应的主要产物。本文报道的产物是已知化合物，并通过GC-MS，IR，1H和13C NMR表征。他们的光谱数据与文献中报道的数据一致。 参考文献：

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