4-氧代哌啶-1-甲酸叔丁酯-3-甲酸甲酯可作为有机合成中间体和医药中间体，用于实验室研发过程和化工医药合成过程中。
医药; 化工合成
合成路线 1（1. 合成：161491-24-3）
- 步骤: 在室温和氮气氛下，向60％氢化钠（3.5g，88mmol）在无水甲苯（50mL）中的悬浮液中滴加碳酸二甲酯（4.32g，48.0mmol）（0.5小时）；加入几滴甲醇后，将N-叔丁氧羰基-4-哌啶酮（4.8g，24mmol）溶于无水甲苯（20mL）的溶液滴加到反应混合物中，保持80℃搅拌；反应后冷却至0℃，用乙酸调节pH至6-6.5，用水（10mL）稀释，5%氢氧化钠溶液调pH至8；分离甲苯层，水层用甲苯（20mL）萃取，合并有机层干燥、浓缩、真空干燥得产物。
- 条件: 氮气保护；80℃搅拌3小时；冰浴冷却；乙酸、5%NaOH调节pH。
- 收率: 80%
- 参考文献: [1] European Journal of Medicinal Chemistry, 2009, vol. 44, #10, p. 4063-4069；[2] Patent: WO2016/123571, 2016, A1. Location in patent: Paragraph 00265；[3] Journal of the American Chemical Society, 2016, vol. 138, #40, p. 13271-13280；[4] Journal of the American Chemical Society, 2015, vol. 137, #21, p. 6738-6741；[5] Patent: CN107163045, 2017, A. Location in patent: Paragraph 0037; 0038；[6] Patent: CN107163046, 2017, A. Location in patent: Paragraph 0041; 0042；[7] Patent: CN107235973, 2017, A. Location in patent: Paragraph 0030; 0033; 0034；[8] Patent: CN107235974, 2017, A. Location in patent: Paragraph 0033; 0034；[9] Patent: CN107141289, 2017, A. Location in patent: Paragraph 0337-0338；[10] Patent: CN107286161, 2017, A. Location in patent: Paragraph 0038; 0041; 0042；[11] Patent: CN107286159, 2017, A. Location in patent: Paragraph 0032; 0036; 0037；[12] Patent: CN107286160, 2017, A. Location in patent: Paragraph 0036; 0039-0040；[13] Patent: CN107266442, 2017, A. Location in patent: Paragraph 0040-0041；[14] Patent: CN107325100, 2017, A. Location in patent: Paragraph 0037-0038；[15] Patent: CN107188892, 2017, A. Location in patent: Page/Page column 0037; 0038；[16] Patent: CN107325094, 2017, A. Location in patent: Paragraph 0038-0039；[17] Patent: CN107151247, 2017, A. Location in patent: Paragraph 0029; 0033; 0034；[18] Patent: CN107325099, 2017, A. Location in patent: Paragraph 0038; 0041; 0042；[19] Patent: CN107383070, 2017, A. Location in patent: Paragraph 0039; 0040；[20] Patent: CN107312000, 2017, A. Location in patent: Paragraph 0039; 0042; 0043；[21] Patent: CN107151248, 2017, A. Location in patent: Paragraph 0031; 0032；[22] Patent: CN107365310, 2017, A. Location in patent: Paragraph 0039; 0043; 0044；[23] Journal of Heterocyclic Chemistry, 2018, vol. 55, #9, p. 2151-2156
合成路线 2（2. 合成：161491-24-3）
- 步骤: 室温下将4-氧代哌啶-3-羧酸甲酯盐酸盐（10.0g，51.6mmol）溶于水（60mL），冷却至0℃；加入碳酸钠（6.02g，56.8mmol），滴加BOC酐（11.84g，51.6mmol）的THF（50mL）溶液；0℃搅拌1小时后，用乙醚（50mL）萃取3次，合并乙醚萃取物，盐水冲洗，硫酸钠干燥，汽提得产物。
- 条件: 0℃搅拌1小时；乙醚萃取；盐水冲洗；硫酸钠干燥。
- 收率: 100%
- 参考文献: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, #5, p. 1375-1378；[2] Patent: US2005/54627, 2005, A1. Location in patent: Page/Page column 114；[3] Patent: US2005/182095, 2005, A1. Location in patent: Page/Page column 18；[4] Patent: WO2010/53438, 2010, A1. Location in patent: Page/Page column 128；[5] Patent: EP1204659, 2003, B1. Location in patent: Page/Page column 24；[6] Patent: EP1204660, 2004, B1. Location in patent: Page 13；[7] European Journal of Organic Chemistry, 2002, #9, p. 1505-1508；[8] Patent: US2009/325948, 2009, A1. Location in patent: Page/Page column 91；[9] European Journal of Organic Chemistry, 2014, vol. 2014, #20, p. 4335-4341；[10] Patent: US2012/88750, 2012, A1. Location in patent: Page/Page column 28; 29；[11] Patent: US6562811, 2003, B1；[12] Patent: US5376666, 1994, A；[13] Patent: WO2008/31772, 2008, A1. Location in patent: Page/Page column 97-98；[14] Journal of Medicinal Chemistry, 2010, vol. 53, #13, p. 4989-5001；[15] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, #23, p. 5478-5483；[16] Patent: US2016/31908, 2016, A1. Location in patent: Paragraph 1392
合成路线 3（3. 合成：161491-24-3）
- 步骤: L-苄基-4-氧代哌啶-3-羧酸甲酯盐酸盐（5.00g，17.6mmol）、三乙胺（2.45mL，17.6mmol）和Boc20（4.20g，20.0mmol）在乙醇（30mL）中的悬浮液，用N2吹扫后加入PD/C（10%，600mg），H2吹扫后在H2-大气压下搅拌24小时，过滤，减压蒸发，柱层析（EtOAc/庚烷1:4至2:3）纯化得产物。
- 条件: N2吹扫；H2-大气压搅拌24小时；硅藻土过滤；柱层析纯化。
- 收率: 89%
- 参考文献: [1] Patent: WO2004/96769, 2004, A1. Location in patent: Page 21；[2] Patent: WO2004/2957, 2004, A1. Location in patent: Page 44
