6226-25-1 2,2,2-三氟乙基三氟甲烷磺酸酯

运输信息：常温运输。危险描述：危险品运输编号3265，WGK Germany:3，Hazard Note:Irritant，危险等级TOXIC、CORROSIVE（8类），包装类别Ⅱ，海关编码29055900，存储类别6.1A（可燃，急性毒性物质），剧毒。危险性类别：急性毒性类别2（吸入）、类别3（经口），皮肤腐蚀类别1B。危险标志GHS05、GHS06，信号词Danger，防范说明P260、P280、P284、P301+P310、P305+P351+P338、P310，危险性描述H301、H314、H330。

2,2,2-三氟乙基三氟甲烷磺酸酯是一种无色液体，主要用于化学合成。

化学合成

路线1：

• 步骤：将三氟甲磺酸（12.5mL，44.3mmol）和2,2,2-三氟乙醇（6.25mL，62.4mmol）在室温下氮气中搅拌30分钟，然后90℃回流3.5小时，冷却至室温后常压蒸馏（90至91℃）得到目标化合物。
• 条件：20-95℃；3.50小时；惰性气氛（氮气）
• 收率：85%
• 参考文献：[1] Patent: US2014/249162, 2014, A1. Location in patent: Paragraph 0423; 0424; 0425 [2] Patent: EP2781519, 2014, A1. Location in patent: Paragraph 0404; 0405; 0406 [3] Tetrahedron, 1988, vol. 44, # 17, p. 5375 - 5387 [4] Journal of Organic Chemistry, 1984, vol. 49, # 12, p. 2258 - 2273 [5] Journal of Fluorine Chemistry, 2016, vol. 192, p. 131 - 140 [6] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 1375-1377 [7] Patent: US2018/111931, 2018, A1. Location in patent: Paragraph 0794; 0795 [8] Patent: WO2018/138303, 2018, A1. Location in patent: Page/Page column 160; 161 [9] Tetrahedron, 1965, vol. 21, p. 1 - 4 [10] Patent: WO2005/63694, 2005, A1. Location in patent: Page/Page column 123-124 [11] Patent: WO2011/87776, 2011, A1. Location in patent: Page/Page column 74; 78 [12] Patent: WO2012/90969, 2012, A1. Location in patent: Page/Page column 125-127 [13] , Gmelin Handbook: F: PerFHalOrg.2, 1.3.1, page 76 - 99, [14] Patent: KR2015/137095, 2015, A. Location in patent: Paragraph 1991-1994 [15] Patent: US2017/305909, 2017, A1. Location in patent: Paragraph 0772; 0773 [16] Patent: WO2018/5881, 2018, A1. Location in patent: Page/Page column 146

路线2：

• 步骤：在100ml烧瓶中加入50ml（0.297mol）三氟甲磺酸酐和25ml（0.342mol）2,2,2-三氟乙醇，室温氮气中搅拌30分钟，回流3小时，蒸馏后得到目标化合物。
• 条件：氮气氛围；回流3小时
• 收率：73%
• 参考文献：[1] Patent: US5382687, 1995, A [2] Patent: US2001/34343, 2001, A1 [3] Patent: US6423704, 2002, B1 [4] Patent: US5922737, 1999, A [5] Patent: US5932571, 1999, A [6] Patent: US5998439, 1999, A [7] Patent: US6169093, 2001, A