53123-88-9 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-9,27-二羟基-3-[(1R)-2-[(1S,3R,4R)-4-羟基-3-甲氧基环己基]-1-甲基乙基]-10,21-二甲氧基-6,8,12,14,20,26-六甲基-23,27-环氧-3H-吡啶并[2,1-c][1,4]氧杂氮杂环三十一烯-1,5,11,28,29(4H,6H,31H)-五酮

中文名称: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-9,27-二羟基-3-[(1R)-2-[(1S,3R,4R)-4-羟基-3-甲氧基环己基]-1-甲基乙基]-10,21-二甲氧基-6,8,12,14,20,26-六甲基-23,27-环氧-3H-吡啶并[2,1-c][1,4]氧杂氮杂环三十一烯-1,5,11,28,29(4H,6H,31H)-五酮
英文名称: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
CAS号
分子式: C₅₁H₇₉NO₁₃
分子量: 914.17
更新日期: 2026-04-12

名称和标识

中文名: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-9,27-二羟基-3-[(1R)-2-[(1S,3R,4R)-4-羟基-3-甲氧基环己基]-1-甲基乙基]-10,21-二甲氧基-6,8,12,14,20,26-六甲基-23,27-环氧-3H-吡啶并[2,1-c][1,4]氧杂氮杂环三十一烯-1,5,11,28,29(4H,6H,31H)-五酮
英文名: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
CAS号: 53123-88-9
分子式: C51H79NO13
分子量: 914.17
中文别名: 西罗莫司;西罗莫司
英文别名: sila9268a; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; AY 22989; EINECS 262-640-9; RAPA; Rapamycin; RPM; RAPAMUNE; MFCD00867594; Sirolimus; Rapamicin

物化属性

外观与性状: 粉末
形态: 溶液在储存期间颜色可能会变暗
颜色: 无色至黄色
临界压力: 未确定
临界温度: 未确定
储存条件/存储条件: -20 ºC
密度: 1.2±0.1 g/cm3
折射率: 1.551
敏感性: Moisture Sensitive/Light Sensitive/Hygroscopic
比旋光度: D25 -58.2° (methanol)
水溶解性: Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
沸点: 973.0±75.0 °C at 760 mmHg
油水（辛醇/水）分配系数的对数值: 未确定
溶解度/溶解性: 乙醇：可溶2MM
熔点: 183-184
燃烧热: 未确定
爆炸上限（%,V/V）: 未确定
爆炸下限: 未确定
相对蒸汽密度（空气=1）: 未确定
稳定性: 如果遵照规格使用和储存则不会分解，未有已知危险反应
精确质量: 913.555115
自燃点或引燃温度: 未确定
蒸气压: 0.56 hPa ( 20 °C)
蒸气压/蒸汽压: 0.0±0.6 mmHg at 25°C
酸度系数(pKa): 10.40±0.70(Predicted)
闪点: 542.3±37.1 °C
饱和蒸气压: 未确定
LogP: 3.54
PSA: 195.43000
外观性质: 黄色固体或粉末，溶液在储存期间颜色可能会变暗（无色至黄色）

安全信息

安全说明

危险品运输编号UN 1648 3 / PGII，WGK Germany 2，RTECS号VE6250000，自燃温度301°C，海关编码29349990，存储类别11 - 可燃固体，危险性类别致癌性类别2、生殖毒性类别2，LD50 in mice (mg/kg): 600 i.p.；>2,500 orally (Vézina)。

生产及用途

用途与制备

作为免疫抑制剂，用于预防器官移植排斥反应（尤其肾移植）；治疗自身免疫性疾病；作为mTOR靶向抑制剂，用于肾癌、淋巴瘤、肺癌等肿瘤治疗；可与葡萄柚汁联用提高生物利用度以增强抗癌效果；还可用于治疗阿尔茨海默症（实验阶段）。

医药

雷帕霉素主要通过发酵法制备：从智利复活节岛土壤中分离的链霉菌（Streptomyces）发酵产生，发酵收得率较低，提取工艺较复杂。目前研究显示可通过前体定向生物合成、诱变生物合成与组合生物合成等方式获得其衍生物以提高活性。

词条详情加载中…

53123-88-9 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-9,27-二羟基-3-[(1R)-2-[(1S,3R,4R)-4-羟基-3-甲氧基环己基]-1-甲基乙基]-10,21-二甲氧基-6,8,12,14,20,26-六甲基-23,27-环氧-3H-吡啶并[2,1-c][1,4]氧杂氮杂环三十一烯-1,5,11,28,29(4H,6H,31H)-五酮

中文名称

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-9,27-二羟基-3-[(1R)-2-[(1S,3R,4R)-4-羟基-3-甲氧基环己基]-1-甲基乙基]-10,21-二甲氧基-6,8,12,14,20,26-六甲基-23,27-环氧-3H-吡啶并[2,1-c][1,4]氧杂氮杂环三十一烯-1,5,11,28,29(4H,6H,31H)-五酮

英文名称

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

CAS号

分子式

C₅₁H₇₉NO₁₃

分子量

914.17

更新日期

2026-04-12