丙二酸单乙酯钾盐是一种有效的制备β-酮酸酯的试剂,在医药及农药兽药等关键中间体中广泛运用,是琥珀酸脱氢酶的竞争性抑制剂,可用于化学合成;其在水中溶解性好,能溶解于N,N-二甲基甲酰胺、四氢呋喃等强极性有机溶剂,常温常压下为白色固体,稳定性好,便于运输。
医药中间体; 农药中间体
合成路线1
- 步骤: 在2升圆底烧瓶中加入丙二酸二乙酯(100g,0.625mol)和乙醇(400ml),磁力搅拌;室温下滴加KOH(35g,0.624mol)的乙醇(400ml)溶液,搅拌过夜;加热至回流后缓慢冷却至室温;通过2号烧结玻璃漏斗真空过滤分离第一批产物并干燥1小时;母液减至500ml后冷却至室温,分离第二批晶体。
- 条件: 反应在乙醇中进行,温度先为20℃(室温),后加热至回流,最终冷却至室温。
- 收率: 总产量97.7g,收率92%。
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