194920-62-2 N-Boc-4,7,10-三氧杂-1,13-十三烷二胺

运输方式为冰袋运输。危险性质：非危险化学品。WGK Germany:3。海关编码:2924190090。存储类别:10 - 可燃性液体。

化学合成；作为保护性连接基使用。

化学合成; 保护性连接基

合成路线 1（1. 合成：194920-62-2）

• 步骤: 通过加料漏斗在0℃下向胺S8（20mL，91.2mmol）的CH₂Cl₂（100mL）溶液中滴加Boc₂O（1.99g，9.12mmol）的CH₂Cl₂（55mL + 5mL冲洗液）溶液。加完后，将反应混合物温热至室温，3小时后，用H₂O（100mL）淬灭。分离两层，有机相用H₂O（3×50mL）和盐水（50mL）洗涤，干燥（MgSO₄），过滤，真空浓缩，得到2.571g（88％）S9，为无色液体。
• 条件: 0 - 20℃；反应时间3小时
• 收率: 88%
• TLC: Rf = 0.14（10％MeOH，0.5％NH₄OH在CH₂Cl₂中）
• 1H-NMR: δ5.10（br s，1H），3.51-3.64（m，12H），3.61（s，4H），3.21（m，2H），2.79（t，J = 6.7 Hz，1H），1.77-1.68（m，4H），1.42（s，9H）ppm
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