2,6-二氯-3,4-吡啶二胺是一种重要的医药中间体，用于合成相关药物分子，其分子离子峰（MH+）为178，保留时间0.57分钟。
医药
合成路线 1（1. 合成：101079-63-4）
产率：95%
合成条件：With hydrogenchloride; iron In ethanol; water at 100℃; for 3 h;
实验步骤：向中间体12（37.00g，177.88mmol）的HCl（60mL）溶液和（EtOH / H 2 O溶液（400mL，1：1，v / v））中加入铁粉（30.00g，537.20mmol）。 将反应混合物在100℃下搅拌3小时，浓缩反应混合物并用水稀释，悬浮的溶液用NaHCO3水溶液碱化至pH = 9.过滤沉淀物，用EtOAc / MeOH混合物稀释（ 过滤剩余的固体，真空浓缩滤液，得到第一批中间体13。
参考文献：
- [1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 1, p. 42 - 46 [2] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 67 [3] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144 [4] Patent: WO2012/167733, 2012, A1. Location in patent: Page/Page column 35 [5] Patent: WO2012/167423, 2012, A1. Location in patent: Page/Page column 32 [6] Patent: US2014/121200, 2014, A1. Location in patent: Paragraph 0143; 0146 [7] Journal of Heterocyclic Chemistry, 1965, vol. 2, p. 196,200 [8] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144 [9] Patent: WO2007/61692, 2007, A2. Location in patent: Page/Page column 115 [10] Patent: WO2007/61694, 2007, A2. Location in patent: Page/Page column 112 [11] Patent: WO2006/31491, 2006, A2. Location in patent: Page/Page column 42; 79 [12] Synthetic Communications, 2010, vol. 40, # 20, p. 2988 - 2999 [13] Patent: WO2012/123312, 2012, A1. Location in patent: Page/Page column 62-63 [14] Patent: WO2008/153852, 2008, A1. Location in patent: Page/Page column 75 [15] Patent: US2014/5188, 2014, A1. Location in patent: Paragraph 0559; 0560; 0561 [16] European Journal of Organic Chemistry, 2014, vol. 2014, # 1, p. 231 - 236
