2,4-二氯噻吩并[3,2-d]嘧啶主要作为医药中间体或农药中间体，用于相关药物和农药的合成制备。
医药; 农药
合成路线 1（1. 合成：16234-14-3）
产率：100%
合成条件：for 2 h; Heating / reflux
实验步骤：向尿嘧啶（5g，29mmol）在POCl 3（40mL）中的悬浮液中加入二异丙基乙胺（13mL，74mmol）并将反应物加热回流2小时。 然后通过减压蒸馏除去过量的POCb和二异丙基乙胺，将得到的棕色固体溶解在氯仿中并用水分配。 通过加入5M NaOH使水相呈碱性，再用氯仿萃取两次。 将合并的有机级分用水和盐水洗涤，干燥（Na 2 SO 4），过滤并浓缩，得到产物，为浅棕色固体（6.05g，定量收率）。 1 H NMR（CDCl 3,300MHz）：8.16（d，J = 5.4Hz，1H），7.56（d，J = 5.7Hz，1H）; LRMS（ESI）：m / z计算值[M + H] + 204.94,206.94，实测值205.1,207.0。
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