34837-84-8 2-(4-氟苯基)乙酸甲酯

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合成路线 3（3. 合成：34837-84-8）

产率：50% 合成条件：With 3-chloro-benzenecarboperoxoic acid; copper(ll) bromide In 1,4-dioxane at 70℃; for 3 h; 实验步骤：通用方法：向m-CPBA（1.2mmol）和CuBr 2（0.1mmol）的无水1,4-二恶烷（10mL）溶液中滴加化合物1（1mmol）的溶液。 将反应混合物在指定温度下搅拌直至TLC显示起始军用化合物1的消耗。反应完成后，使反应混合物冷却至室温，并加入EtOAc（20mL）。 将所得混合物用饱和Na 2 S 2 O 3水溶液（10mL）和饱和Na 2 CO 3水溶液（10mL）洗涤。 将有机层用无水Na 2 SO 4干燥，过滤，并在减压下除去。 通过硅胶快速柱色谱法纯化残余物，得到所需产物。 参考文献：

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