133550-35-3 (E)-2-氰基-3-(3,4-二羟基苯基)-N-苯基丙烯酰胺

危险性质：非危险化学品

• 生物活性 AG-494是EGFR受体自身磷酸化的抑制剂，IC50为1.2 μM。它抑制依赖于EGF的细胞生长，IC50为6 μM。
• 靶点 Target Value EGFR (Cell-free assay) 1.2 μM
• 体外研究 In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis. AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H 2 O 2 -treated cells. AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.

医药