化学合成。
化学合成
合成路线 1（1. 合成：40004-69-1）
产率：70%
合成条件：Stage #1: With water; sodium hydroxide In 1,4-dioxane at 20℃; for 1 h; Stage #2: With hydrogenchloride In 1,4-dioxane; water
实验步骤：b）2-甲基 - 噻唑-5-羧酸在室温下向搅拌的2-甲基 - 噻唑-5-羧酸乙酯（1.3g，8.0mmol）的二恶烷（12mL）溶液中加入NaOH（2N） ，12毫升）。 1小时后，将反应混合物用HCl（1N，12mL）中和，然后过滤，将收集的固体真空干燥，得到标题化合物（758mg，70％），为灰白色固体。 MS：m / e = 142.0 [M-H]“。
参考文献：
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