炔丙基丙二酸二甲酯主要用于医药和农药领域的有机合成反应，作为关键中间体参与多种化学反应。
医药; 农药
合成路线 1（1. 合成：95124-07-5）
产率：67%
合成条件：Stage #1: at 0 - 20℃; for 1.25 h; Stage #2: at 0 - 20℃;
实验步骤：一般步骤：在室温下将小Na片（2.30g，100mmol）小心地加入EtOH（100mL）中。在将制备的EtONa溶液冷却至0℃后，在10分钟内将丙二酸二乙酯（16.0g，100mmol）加入到搅拌的溶液中。 15分钟后，将溶液温热至室温并搅拌50分钟。将烯醇化物溶液再冷却至0℃，并在20分钟内加入3-溴丙炔（11.9g，100mmol）。 30分钟后，将溶液温热至室温并搅拌过夜。蒸发反应混合物并用H 2 O洗涤。将水层用Et 2 O萃取两次。将合并的有机层用Na 2 SO 4干燥并蒸发。通过蒸馏和硅胶柱色谱（己烷-AcOEt 10：1）纯化残余油，得到（丙-2-炔基）丙二酸二乙酯（11.9g，60.0mmol），产率60％。该产物也由三乙基十二烷基甲酸盐 - 氧化物和3-溴丙炔制备。 2丙二酸二乙酯（丙-2-炔基）：
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