4354-73-8 2-亚环己基丙二腈

运输信息：常温运输。危险描述：非危险化学品。

化学合成。

化学合成

合成路线 1（1. 合成：4354-73-8）

产率：100% 合成条件：at 25℃; for 2 h; 实验步骤：相应的反应（a）至（p）是通过在搅拌下和在5ml溶剂（二甲基甲酰胺（己烷）DMF或乙腈（MeCN））中，1毫摩尔羰基化合物和1毫摩尔活化甲醇的反应实现的。 在实施例1中制备0.0035g'HDT-F'催化剂。在每种情况下，通过在板上进行色谱法跟踪反应进程。 在反应结束时，过滤催化剂，滤液用水洗涤，产物用硫酸钠萃取并在低压下浓缩。 基于在最终培养基中观察到的NMR光谱，基于反应过程中消耗的R1R2CO酮化合物计算所示产率。 参考文献：[1] Patent: US2005/250963, 2005, A1. Location in patent: Page/Page column 5 [2] Green Chemistry, 2010, vol. 12, # 3, p. 514 - 517 [3] Synlett, 2000, # 7, p. 1016 - 1018 [4] Collection of Czechoslovak Chemical Communications, 2005, vol. 70, # 10, p. 1727 - 1736 [5] European Journal of Organic Chemistry, 2008, # 28, p. 4763 - 4768 [6] RSC Advances, 2013, vol. 3, # 45, p. 23075 - 23079 [7] Russian Chemical Bulletin, 2013, vol. 62, # 3, p. 683 - 686 [8] Izv. Akad. Nauk, Ser. 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Chem., 2016, vol. 128, p. 9206 - 9210,5 [82] Monatshefte fur Chemie, 2016, vol. 147, # 7, p. 1243 - 1249 [83] Molecules, 2016, vol. 21, # 12, [84] Polymer, 2017, vol. 112, p. 342 - 350 [85] Molecular Catalysis, 2018, vol. 453, p. 93 - 99 [86] Green Chemistry, 2018, vol. 20, # 23, p. 5336 - 5345 以环己酮和丙二腈为原料合成2-环己基亚己基丙二腈的一般步骤如下：在搅拌条件下，将1毫摩尔环己酮（羰基化合物）和1毫摩尔丙二腈（活化甲醇）溶于5毫升溶剂（二甲基甲酰胺（DMF）或乙腈（MeCN））中。加入0.0035克'HDT-F'催化剂（如实施例1所述制备）。反应进程通过薄层色谱法（TLC）监测。反应完成后，过滤去除催化剂，滤液用水洗涤，产物用硫酸钠干燥后，在减压条件下浓缩。产率基于反应过程中消耗的环己酮量，通过核磁共振（NMR）光谱分析最终产物确定。 参考文献：[1] Patent: US2005/250963, 2005, A1. Location in patent: Page/Page column 5 [2] Green Chemistry, 2010, vol. 12, # 3, p. 514 - 517 [3] Synlett, 2000, # 7, p. 1016 - 1018 [4] Collection of Czechoslovak Chemical Communications, 2005, vol. 70, # 10, p. 1727 - 1736 [5] European Journal of Organic Chemistry, 2008, # 28, p. 4763 - 4768