化学合成。
化学合成
合成路线 1（1. 合成：1201-93-0）
产率：97%
合成条件：at 140℃; for 12 h;
实验步骤：在100mL干燥圆底烧瓶中，加入苯乙酮1.08g（9mmol）N，N-二甲基甲酰胺二甲基缩醛3.9mL（30mmol）和30mL二甲苯作为溶剂。 将混合物在140℃下回流12小时。 在TLC检测反应完成后，停止加热，减压除去溶剂，通过快速柱色谱分离粗产物，得到浅黄色固体N，N-（二甲基氨基）-1-苯基烯胺酮1.48 g（产率97％）。
参考文献：
- [1] RSC Advances, 2017, vol. 7, # 45, p. 28483 - 28488 [2] Patent: CN108383763, 2018, A. Location in patent: Paragraph 0044; 0046 [3] Patent: US2011/195993, 2011, A1. Location in patent: Page/Page column 10; 14 [4] Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4857 - 4860 [5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 4, p. 1214 - 1217 [6] Organic Process Research and Development, 2008, vol. 12, # 3, p. 490 - 495 [7] Patent: WO2014/125426, 2014, A1. Location in patent: Page/Page column 54; 55 [8] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5609 - 5613 [9] Patent: WO2010/129049, 2010, A1. Location in patent: Page/Page column 114; 118 [10] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 15, p. 4528 - 4532 [11] Chemical Communications, 2016, vol. 52, # 83, p. 12306 - 12309 [12] Molecules, 2017, vol. 22, # 12, [13] Patent: WO2006/123648, 2006, A1. Location in patent: Page/Page column 20 [14] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 6, p. 1707 - 1710 [15] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 8, p. 2742 - 2750 [16] Patent: EP3287456, 2018, A1. Location in patent: Paragraph 0175 [17] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 837 - 843 [18] Journal of the Chinese Chemical Society, 2003, vol. 50, # 2, p. 283 - 296 [19] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 3055 - 3057 [20] Journal of the American Chemical Society, 2010, vol. 132, # 44, p. 15531 - 15533 [21] Journal of the Indian Chemical Society, 2010, vol. 87, # 6, p. 739 - 742 [22] ACS Combinatorial Science, 2011, vol. 13, # 4, p. 427 - 435 [23] Synthetic Communications, 2012, vol. 42, # 10, p. 1521 - 1531 [24] Tetrahedron, 2012, vol. 68, # 25, p. 5046 - 5052 [25] Organic Letters, 2012, vol. 14, # 15, p. 3920 - 3923 [26] Tetrahedron Letters, 2013, vol. 54, # 21, p. 2612 - 2614 [27] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1581 - 1588 [28] Medicinal Chemistry Research, 2015, vol. 24, # 6, p. 2742 - 2755 [29] Synthetic Communications, 2015, vol. 45, # 16, p. 1902 - 1911 [30] Journal of Heterocyclic Chemistry, 2015, vol. 52, # 5, p. 1296 - 1301 [31] Synthetic Communications, 2015, vol. 45, # 23, p. 2683 - 2690 [32] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 8, p. 1749 - 1756 [33] New Journal of Chemistry, 2016, vol. 40, # 5, p. 4705 - 4709 [34] Chemistry - A European Journal, 2016, vol. 22, # 29, p. 9966 - 9970 [35] Molecules, 2015, vol. 20, # 5, p. 8800 - 8815 [36] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 23, p. 6166 - 6173 [37] European Journal of Medicinal Chemistry, 2017, vol. 128, p. 1 - 12 [38] Letters in Organic Chemistry, 2017, vol. 14, # 5, p. 353 - 360 [39] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 545 - 551 [40] European Journal of Medicinal Chemistry, 2018, vol. 152, p. 307 - 317 [41] Patent: WO2018/142365, 2018, A1. Location in patent: Page/Page column 66 [42] Bioorganic Chemistry, 2019, vol. 83, p. 549 - 558 [43] Chemical Communications, 2018, vol. 54, # 99, p. 13953 - 13956
