5271-67-0 2-噻吩甲酰氯

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合成路线 3（3. 合成：5271-67-0）

产率：93% 合成条件：at 200℃; for 0.75 h; 实验步骤：装置：来自ISCO的活塞泵260D TeledyneDEVICE 1：管式反应器，长度为6米，内部容积为96.16毫升，外径为0.25英寸.DEVICE3：压力控制阀世伟洛克BPV-SS-07含有90％重量的混合物MIX1 摩尔比为2：1的草酰氯和噻吩的混合物MIX2和10％（重量）环丁砜（wtlcent，基于M1xi的总重量）由DEVICEO以2.14mL / min的速率通过装置1以averagePRESS进料。 80 bar中的1个，通过DEVICE3调整和保持。 通过加热流体将装置1保持在200℃的温度。 装置1中混合物的停留时间TIME1为45mm。 收集反应混合物的液体样品，并用内标二恶烷通过1H NMR分析，基于噻吩，噻吩-2-碳酰氯的产率为93％。 参考文献：

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