苄基(2-羟乙基)氨基甲酸叔丁酯主要用于医药领域,作为中间体或原料参与相关药物合成。
医药
合成路线 1(1. 合成:121496-39-7)
产率:100%
合成条件:With sodium hydroxide In dichloromethane; water at 20℃; for 24 h;
实验步骤:将二碳酸二叔丁酯(0.01mol)的CH 2 Cl 2(15ML)溶液滴加到2-苄基氨基乙醇(0.01MOL)在15ML CH 2 Cl 2和12ML 1M NaOH中的溶液中。 在室温下搅拌24小时后,分离有机层,用水(25mL X 2)洗涤,用无水Na 2 SO 4干燥。减压除去溶剂,得到粗产物,为油状物,通过柱色谱(二氧化硅)纯化。 凝胶,己烷:EtOAc,7:3)(100%)。
参考文献:
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