化学合成。
化学合成
合成路线 1（1. 合成：21080-80-8）
产率：93%
合成条件：With sodium In ethanol at 0 - 80℃; Inert atmosphere
实验步骤：在室温和氮气氛下将金属钠溶解在EtOH（150ml）溶液中以形成NaOEt（16.19g）。 将该混合物冷却至0℃。 逐滴加入草酸二乙酯（34.76g）和异丙基甲基酮（20gm）约15分钟并温热至室温。 现在加入EtOH（100ml）并在室温下搅拌约1小时。 将该反应混合物加热至80℃约45分钟并冷却至室温并减压浓缩。 为此产生的固体，添加EtOAC。 用EtOH洗涤，在布上过滤，得到细粉末。将该固体溶于水中，用稀硫酸（pH-2）酸化。 该化合物用乙醚萃取，用硫酸钠干燥，减压浓缩，得到棕色液体化合物（40g，收率93％）。
参考文献：
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