39098-97-0 2-噻吩乙酰氯

运输信息：冰袋运输。危险描述：危险品运输编号UN 3265 8/PG 2，危险等级8，包装类别III，信号词Danger，危险标志GHS05、GHS07，补充危害声明与水剧烈反应，危险性防范说明P261、P280、P305+P351+P338、P310，危险性描述H314、H335，WGK Germany:3，F:8-10-21，TSCA:TSCA listed，海关编码29349990。

化学合成；用作医药中间体

医药

路线1：

• 步骤: 四口烧瓶中加入71.6g 2-噻吩乙酸、6.3g DMF、350g二氯甲烷，搅拌溶解并冷却至-10℃，滴加1101.3g三光气与300g二氯甲烷的混合溶液，滴加后升温至0℃保温5小时，减压蒸馏除去残留二氯甲烷，收集2-噻吩乙酰氯馏分76.4g。
• 条件: 以二氯甲烷为溶剂，N,N-二甲基甲酰胺为催化剂，三光气为氯化试剂，反应温度-10-0℃，反应时间5小时。
• 收率: 94.7%，HPLC面积归一化含量99.5%。
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