1-(叔丁氧羰基)-2-吡咯烷酮是有用的合成中间体，可用于通过4-组分Ugi反应（异氰化物，羰基化合物，伯胺，羧酸）制备高官能化的N-酰基-2-乙烯基吡咯烷；还可用于通过催化SeO₂氧化合成天然存在的美拉德香料。
化学合成
路线1：
- 步骤：向吡咯烷-2-酮（10.0g，118mmol）的CH₃CN（118mL）溶液中加入TEA（19.6mL，141mmol）、DMAP（7.18g，58.8mmol）和（t-Boc）₂O（32.7g）；在0℃下搅拌至室温并继续搅拌过夜；反应完成后，混合物在EtOAc和水之间分配，有机层依次用1N HCl、1N NaOH和盐水洗涤，用Na₂SO₄干燥，过滤并真空浓缩，经SiO₂柱色谱（Hex:EtOAc=1:1）纯化得到产物。
- 条件：With dmap; triethylamine In acetonitrile at 0 - 20℃;
- 收率：96%
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