作为有机合成中间体,用于医药相关化合物的制备(具体用途未在提供数据中详细说明)
医药
路线1:以3-苄氧基苯甲醇为原料合成3-苄氧基溴苄
- 步骤:向3-苄氧基苯甲醇(3.0g,14.0mmol)的无水乙醚(50mL)溶液中加入PBr₃(0.66mL,7.0mmol),室温搅拌3小时;反应后用乙醚(60mL)稀释,依次用去离子水(2×40mL)、饱和NaHCO₃溶液(2×40mL)、盐水(2×40mL)洗涤;醚层经无水MgSO₄干燥后减压除溶剂,得浅黄色固体产物。
- 条件:以无水乙醚为溶剂,PBr₃为溴化试剂,室温反应3小时。
- 收率:97%。
- 参考文献:
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