622-40-2 2-吗啉乙醇

运输信息：常温运输。危险描述：非危险化学品，WGK Germany:1，RTECS号:QE3510000，F:10-23，TSCA listed，海关编码:29349990，存储类别:10 - 可燃性液体，危险性类别:眼部刺激 类别2

化学合成；化工医药中间体。用于制备萘普生的酯类前药，是合成吗替麦考酚酯、福尔可定、匹维溴铵等医药产品的重要中间体，也用于有机合成。

医药; 化工

路线1：吗啉与2-溴乙醇反应

• 步骤: 将2-溴乙醇（27.9g，223mmol）、吗啉（40g，459mmol）和K₂CO₃（48.4g，350mmol）在CH₃CN（30mL）中的混合物回流3小时，冷却至室温后过滤，滤液真空浓缩得到标题化合物。
• 条件: With potassium carbonate; In acetonitrile; Reflux for 3 h
• 产率: 83%
• 参考文献: [1] Journal of the Indian Chemical Society, 1989, vol. 66, #5, p. 316-318; [2] Patent: WO2014/12360, 2014, A1 (Paragraph 00498); [3] Patent: US2015/87639, 2015, A1 (Paragraph 0849; 0850); [4] Patent: TWI607995, 2017, B (Page/Page column 180); [5] Journal of Organic Chemistry, 2018, vol. 83, #24, p. 15333-15346; [6] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, #3, p. 799-807; [7] Patent: WO2014/198808, 2014, A1 (Page/Page column 119); [8] Patent: WO2017/149518, 2017, A1 (Page/Page column 25); [9] Patent: WO2018/29604, 2018, A1 (Page/Page column 47); [10] Journal of the American Chemical Society, 1955, vol. 77, p. 2855,2857; [11] Patent: WO2014/14698, 2014, A2 (Paragraph 0064; 0074); [12] Patent: EP2813505, 2014, A1 (Paragraph 0157)

路线2：吗啉与环氧乙烷加成

• 步骤: 将环氧乙烷气体通入吗啉中反应，通毕保温半小时，加热蒸除水分，残留液减压蒸馏收集122-126℃（1.33kPa）馏分。
• 条件: Temperature controlled below 20℃ during reaction; After completion, keep warm for 0.5 h; Distillation under reduced pressure
• 产物: 4-(2-羟乙基)吗啉（吗啉乙醇）