446-38-8 3-氟-4-硝基苯甲醚

运输信息：常温运输。危险描述：危险品运输编号3261，WGK Germany 3，危险等级8，包装类别Ⅱ，海关编码2909309090，存储类别8A（可燃，腐蚀性物质），危险性类别含危害水生环境-长期危害（类别3）、严重眼损伤（类别1）、皮肤腐蚀（类别1B）、特异性靶器官毒性-一次接触（类别3），Hazard Note：Irritant/Keep Cold。

3-氟-4-硝基苯甲醚可用作有机合成中间体和医药中间体，主要用于实验室研发过程和化工生产过程中。

医药中间体; 有机合成中间体

路线1：

• 步骤：在环境温度下，向3-氟-4-硝基苯酚（25.3g，0.16mol）的丙酮（160ml）溶液中加入碳酸钾（41.7g，0.30mol）和甲基碘（20.0ml，0.32mol），将反应混合物在40℃下搅拌3小时；冷却至室温后，加入二氯甲烷，过滤并蒸发；向残余物中加入二氯甲烷，有机相用H₂O和盐水洗涤，经硫酸钠干燥并蒸发，得到2-氟-4-甲氧基-1-硝基苯，产率98％。
• 条件：With potassium carbonate In acetone at 20 - 40℃; for 3 h;
• 收率：98%
• 参考文献：[1] Chemistry - A European Journal, 2009, vol. 15, # 4, p. 885 - 900 [2] Chemistry - A European Journal, 2014, vol. 20, # 39, p. 12553 - 12558 [3] Patent: WO2004/76455, 2004, A1. Location in patent: Page 24 [4] Patent: US2007/232603, 2007, A1. Location in patent: Page/Page column 16 [5] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9599 - 9605 [6] Patent: WO2007/36711, 2007, A1. Location in patent: Page/Page column 48 [7] Organic and Biomolecular Chemistry, 2007, vol. 5, # 22, p. 3665 - 3673 [8] Patent: WO2004/9583, 2004, A2. Location in patent: Page 190 [9] Patent: US2005/38076, 2005, A1. Location in patent: Page/Page column 28 [10] Patent: US2005/38076, 2005, A1. Location in patent: Page/Page column 21 [11] Patent: WO2015/175845, 2015, A1. Location in patent: Paragraph 0303 [12] Patent: WO2012/136492, 2012, A1. Location in patent: Page/Page column 56-57 [13] Patent: US2014/5164, 2014, A1. Location in patent: Paragraph 0238-0240 [14] Journal of Medicinal Chemistry, 1990, vol. 33, # 1, p. 286 - 291 [15] Patent: US5262390, 1993, A [16] Patent: US5362747, 1994, A [17] Patent: US5399543, 1995, A [18] Patent: WO2004/69256, 2004, A1. Location in patent: Page/Page column 44-45 [19] Patent: US2004/204427, 2004, A1. Location in patent: Page/Page column 20