58584-92-2 2-氨基-6-氯烟酸

运输方式为冰袋运输。危险性质：非危险化学品。WGK Germany:3，危险等级:IRRITANT，海关编码:2936290000

2-氨基-6-氯烟酸可用作有机合成中间体和医药中间体，主要用于实验室研发过程和医药化工生产过程中。

医药; 农药

路线1：

• 步骤: 将2,6-二氯吡啶-3-羧酸（3g，0.0157mol）的氨水（30mL）溶液在密封管中于130℃加热12小时，浓缩后用乙醚研磨粗固体得标题化合物。
• 条件: 130℃，密封管，12小时。
• 产率: 93%。
• 参考文献: [1] Patent: WO2016/198400, 2016, A1. Location in patent: Page/Page column 65 [2] Patent: WO2007/60404, 2007, A1. Location in patent: Page/Page column 57-58 [3] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 99 [4] Patent: US2009/99174, 2009, A1 [5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1212 - 1216 [6] Patent: US2003/199511, 2003, A1. Location in patent: Page/Page column 46 [7] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 42 [8] Patent: EP1864980, 2007, A1. Location in patent: Page/Page column 37 [9] Patent: EP1669348, 2006, A1. Location in patent: Page/Page column 50 [10] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 2206 - 2210 [11] Patent: US2010/222319, 2010, A1. Location in patent: Page/Page column 14 [12] Patent: US2009/82403, 2009, A1. Location in patent: Page/Page column 74 [13] Patent: US2007/105904, 2007, A1. Location in patent: Page/Page column 71 [14] Patent: US2006/14708, 2006, A1. Location in patent: Page/Page column 11 [15] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 42 [16] Patent: EP1669348, 2006, A1. Location in patent: Page/Page column 50 [17] Patent: EP2065377, 2009, A1. Location in patent: Page/Page column 73-74 [18] Patent: WO2010/38060, 2010, A1. Location in patent: Page/Page column 98 [19] Patent: EP2248423, 2010, A1. Location in patent: Page/Page column 269

路线2：

• 步骤: 将2,6-二氯烟酸（40g，纯度90%，0.19mol）、乙酰胺（80g，1.4mol）、碳酸钾（78g，0.56mol）、氯化铜（I）（0.93g，9.4mmol）和二甲苯（80mL）混合，加入三（2-（2-甲氧基乙氧基）乙基）胺（3.0mL，9.4mmol），145℃搅拌过夜；加入氯化铜（I）（0.46g，4.6mmol），145℃搅拌过夜；冷却至105℃，加水（100mL）搅拌1小时，冷却至室温；用5N盐酸和柠檬酸水溶液中和，加乙酸乙酯，硅藻土过滤，有机相饱和氯化钠洗涤，减压浓缩，硅胶柱色谱（乙酸乙酯）精制，乙酸乙酯-己烷重结晶得标题化合物。
• 条件: Stage #1: 145℃，xylene，过夜；Stage #2: 145℃，xylene，过夜；冷却至105℃，加水搅拌1小时。
• 产率: 4.5%。
• 参考文献: [1] Patent: EP1864980, 2007, A1. Location in patent: Page/Page column 37-38