5597-50-2 对羟基苯丙酸甲酯

运输方式：冰袋运输。危险性质：非危险化学品。WGK Germany:3。海关编码:29181990。存储类别:11 - 可燃固体。危险性类别:眼部刺激 类别2；经皮刺激 类别2；特异性靶器官毒性-一次接触，类别3。

对羟基苯丙酸甲酯是一种有机中间体，可用于制备稳定性肥料和盐酸艾司洛尔光学异构体；也可通过酯化反应制备，如对羟基苯丙酸与甲醇在硫酸催化下加热回流反应得到。

化学合成中间体

路线1：催化加氢还原

• 原料：（E）-3-（4-羟基苯基）丙烯酸甲酯（1.0g，5.6mmol）
• 步骤：向（E）-3-（4-羟基苯基）丙烯酸甲酯的乙醇（20mL）溶液中加入0.1克钯/碳催化剂，在1巴氢气氛下室温搅拌21小时，反应结束后过滤，真空蒸发至干得到产物。
• 条件：钯/碳催化剂；乙醇溶剂；20℃；氢气氛（1巴）；21小时
• 收率：99%
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路线2：酯化反应

• 原料：3-（4-羟基苯基）丙酸（0.05mmol）；适当的醇（1.0mL）；TMCS（0.1mmol）
• 步骤：向3-（4-羟基苯基）丙酸在TMCS中的悬浮液中加入适当的醇，25℃搅拌24小时，减压蒸发得到产物。
• 条件：25℃；24小时；减压蒸发
• 收率：100%
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