3032-92-6 4-乙炔基苯甲腈

运输信息：常温运输。危险描述：非危险化学品，WGK Germany:3，海关编码2926907090，存储类别11 - 可燃固体，具有眼部刺激（类别2）、经皮刺激（类别2）和特异性靶器官毒性 - 一次接触（类别3）的危险性。

化学合成

化学合成

路线1：以4-[(三甲基硅基)乙炔基]苄腈为原料

• 步骤: 向4-[(三甲基硅基)乙炔基]苄腈（1.1g，5.3mmol）的甲醇/四氢呋喃（16mL，1:1）混合溶液中加入碳酸钾（50mg，0.36mmol），室温搅拌30分钟，旋转蒸发除去溶剂，残余物用乙酸乙酯稀释，依次用10%盐酸水溶液和饱和食盐水洗涤，有机层经无水硫酸镁干燥后减压浓缩，得到4-乙炔基苯甲腈（0.61g，4.80mmol，收率91%）。
• 条件: 20℃，搅拌30分钟，减压浓缩。
• 收率: 91%。
• 参考文献: [1] Tetrahedron, 2003, vol. 59, #3, p.287-293；[2] Journal of Medicinal Chemistry, 1998, vol.41, #21, p.4036-4052；[3] Journal of the American Chemical Society, 1997, vol.119, #43, p.10401-10412；[4] Journal of Organic Chemistry, 2014, vol.79, #16, p.7342-7357；[5] New Journal of Chemistry, 2017, vol.41, #6, p.2296-2308；[6] Journal of Materials Chemistry C, 2015, vol.4, #1, p.193-200；[7] Synthesis, 1980, #8, p.627-630；[8] Tetrahedron, 2011, vol.67, #1, p.125-143；[9] Tetrahedron Letters, 2006, vol.47, #46, p.8147-8150；[10] Journal of the American Chemical Society, 2017, vol.139, #14, p.5164-5174；[11] Chemical Communications, 2015, vol.51, #42, p.8825-8828；[12] Organic Letters, 2013, vol.15, #4, p.936-939；[13] Helvetica Chimica Acta, 2000, vol.83, #11, p.2926-2938；[14] Organic Letters, 2012, vol.14, #15, p.3970-3973；[15] Chemistry Letters, 2014, vol.43, #10, p.1548-1550；[16] Chinese Journal of Chemistry, 2015, vol.33, #8, p.967-973；[17] Patent: CN107459438, 2017, A. Location in patent: Paragraph 0070; 0071；[18] Journal of Organic Chemistry, 2005, vol.70, #4, p.1134-1146；[19] Tetrahedron, 2010, vol.66, #29, p.5479-5485；[20] Journal of Medicinal Chemistry, 1997, vol.40, #5, p.717-729；[21] Bioorganic and Medicinal Chemistry, 2010, vol.18, #2, p.557-566；[22] Patent: US2002/169200, 2002, A1；[23] Inorganic Chemistry, 2018, vol.57, #12, p.7208-7221；[24] Journal of Materials Chemistry, 2011, vol.21, #36, p.14041-14047；[25] RSC Advances, 2016, vol.6, #95, p.92845-92851；[26] Patent: WO2006/2099, 2006, A2. Location in patent: Page/Page column 207；[27] Chemical Communications, 2007, #35, p.3637-3639；[28] Organic Letters, 2018, vol.20, #16, p.4880-4884；[29] Australian Journal of Chemistry, 1994, vol.47, #2, p.247-262；[30] Journal of Organic Chemistry, 2004, vol.69, #5, p.1752-1755；[31] Journal of the American Chemical Society, 2005, vol.127, #26, p.9332-9333；[32] Journal of the American Chemical Society, 2006, vol.128, #14, p.4504-4505；[33] Organic Letters, 2006, vol.8, #4, p.717-720；[34] Organic and biomolecular chemistry, 2003, vol.1, #3, p.498-506；[35] Chemistry - A European Journal, 2001, vol.7, #23, p.5118-5134；[36] Journal of Organic Chemistry, 2007, vol.72, #13, p.4750-4755；[37] Journal of Chemical Research, 2008, #12, p.669-678；[38] Journal of Organic Chemistry, 2009, vol.74, #10, p.3776-3782；[39] Tetrahedron, 2010, vol.66, #48, p.9415-9420；[40] Journal of Materials Chemistry, 2010, vol.20, #43, p.9775-9786；[41] Angewandte Chemie - International Edition, 2011, vol.50, #49, p.11777-11781；[42] Chemical Communications, 2012, vol.48, #15, p.2080-2082；[43] Journal of Fluorine Chemistry, 2012, vol.135, p.231-239；[44] Organic Letters, 2012, vol.14, #11, p.2846-2849；[45] Canadian Journal of Chemistry, 2012, vol.90, #11, p.994-1014；[46] Chemistry - A European Journal, 2014, vol.20, #10, p.2746-2749；[47] Chemical Communications, 2014, vol.50, #57, p.7666-7669；[48] Organic Letters, 2014, vol.16, #24, p.6302-6305；[49] Organic Letters, 2014, vol.16, #18, p.4722-4725；[50] Tetrahedron Letters, 2015, vol.56, #51, p.7105-7107；[51] Angewandte Chemie - International Edition, 2016, vol.55, #19, p.5754-5759；[52] Angew. Chem., 2016, vol.128, p.5848-5853,6；[53] Patent: WO2016/55947, 2016, A1. Location in patent: Page/Page column 60；[54] European Journal of Organic Chemistry, 2016, vol.2016, #18, p.3056-3059；[55] Journal of Organic Chemistry, 2018, vol.83, #4, p.2250-2255。