142253-55-2 1-Boc-氮杂环丁烷-3-羧酸

运输方式：冰袋运输。危险描述：非危险化学品，危险等级为IRRITANT（刺激性），WGK Germany:3，TSCA:No，海关编码29339900，存储类别13 - 不可燃性固体。

化学合成，是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子(ADCs)；生命科学。

医药; 生命科学

路线1：

• 步骤: 将溶解在MeOH（70mL）中的91（BoC）₂O（25.535g，117mmol）在20分钟内滴加到氮杂环丁烷-3-羧酸（10.11g，100mmol）和Et₃N（27.8mL，200mmol）的搅拌浆液中。在室温下（轻度放热反应）在MeOH（105mL）中的MeOH（105mL）并将混合物5搅拌过夜（18小时）。将反应混合物蒸发至干，加入THF（120mL）并蒸发，得到粗1-（叔丁氧基羰基）氮杂环丁烷-3-羧酸，其不经进一步纯化用于下一步骤。
• 条件: With triethylamine In methanol at 20℃; for 18 h;
• 收率: 25.89克（128％）
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