2-溴-4-叔丁基苯酚主要用于医药和农药领域,具体用途需结合具体应用场景进一步研究。
医药; 农药
合成路线 1(1. 合成:2198-66-5)
产率:100%
合成条件:With bromine In tetrachloromethane; chloroform at 0℃; Inert atmosphere
实验步骤:在2小时内将溴(7.18mL,0.14mol)的氯仿(25mL)溶液滴加到4-叔丁基 - 苯酚(20g,0.133mol)在1:1v / v氯仿中的溶液中: 在氮气下,在0℃下加入四氯化碳(64mL)直至持续出现轻微的红色着色(剩余约1mL溴溶液)。 然后将反应混合物用氮气吹扫过夜。 将得到的棕褐色溶液用二氯甲烷(50mL)稀释,用1%硫代硫酸钠水溶液(100mL)和饱和盐水(100mL)洗涤,干燥(MgSO 4),过滤并减压浓缩,得到2-溴-4 - (叔丁基)苯酚(30.5g,定量收率),为无色油状物。
参考文献:
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