6-溴-2-氯喹啉是冶金、染料、聚合物以及农用化学品工业的重要中间体，也可以用作消毒剂、防腐剂以及溶剂。
医药; 农药; 染料; 聚合物; 农用化学品; 消毒剂; 防腐剂; 溶剂
路线1：
- 步骤: 将6-溴喹啉-2（1 / - ） - 酮（1.0g，4.4mmol，1.0当量）在磷酰氯（15mL）中的搅拌溶液加热至100℃，保持15小时。将溶剂完全蒸发并将水加入残余物中。过滤沉淀的固体并在真空下干燥，得到粉红色固体状的6-溴-2-氯喹啉（1.0g，92％）。
- 条件: at 100℃; for 15 h
- 产率: 92%
- 参考文献: [1] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 78 [2] Journal of the American Chemical Society, 2016, vol. 138, # 25, p. 7808 - 7811 [3] Patent: WO2006/132739, 2006, A2. Location in patent: Page/Page column 36 [4] European Journal of Medicinal Chemistry, 2000, vol. 35, # 10, p. 931 - 940 [5] Patent: WO2009/39127, 2009, A1. Location in patent: Page/Page column 181 [6] Patent: WO2009/39134, 2009, A1. Location in patent: Page/Page column 110 [7] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 22, p. 5907 - 5912 [8] Patent: WO2005/75428, 2005, A1. Location in patent: Page/Page column 31-32 [9] Patent: WO2007/14941, 2007, A2. Location in patent: Page/Page column 36-37 [10] Journal of Medicinal Chemistry, 1988, vol. 31, # 10, p. 2048 - 2056 [11] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 18, p. 2753 - 2758 [12] Patent: WO2004/24731, 2004, A1. Location in patent: Page 50 [13] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 6, p. 508 - 518 [14] Patent: WO2015/96035, 2015, A1. Location in patent: Page/Page column 53; 54 [15] Patent: WO2015/100147, 2015, A1. Location in patent: Page/Page column 54
