二糠基二硫醚具有坚果香、咖啡香和肉香，可用于调配各种食用香精，在软饮料、冰淇淋、冰制食品、糖果、烘烤食品、胶冻及布丁、口香糖、调味料、肉、肉汁、汤类、牛奶、乳制品等食品中的报导用量为3.0ppm；FEMA(mg/kg)：软饮料、冷饮、糖果、焙烤食品、胶冻、布丁、胶姆糖、调味料、肉制品、肉羹汤、牛奶、乳制品，均3.0；GB 2760-1996规定为暂时允许使用的食品用香料；广泛用作配制食用香精的原料，产品有多种规格,含量为95%～98%。
食品用香料
合成路线 1（1. 合成：4437-20-1）
- 产率：95%
- 合成条件：With potassium bromate; hexaammonium heptamolybdate tetrahydrate In water; acetonitrile at 20℃; for 0.25 h;
- 实验步骤：将4-氯苯硫酚（0.145g，1mmol）加入到KBrO3（0.167g，1mmol），（NH4）6Mo7O24·4H2O（0.124g，10mmol）和CH3CN / H2O的非均相混合物中（7：3）（5mL）并将混合物在通风橱中在环境气氛和室温下搅拌4分钟。通过TLC监测反应进程（洗脱液：EtOAc / n-C6H14,1 / 13）。完成后，加入CH2Cl2（20mL）并过滤反应混合物。将滤液用5％NaOH，水洗涤，并用无水MgSO4干燥。最后，蒸发溶剂，得到具有足够纯度的产物
- 参考文献：[1] Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 3, p. 685 - 691 [2] Synthesis, 2007, # 21, p. 3286 - 3289 [3] Journal of Chemical Research - Part S, 2002, # 11, p. 564 - 566 [4] Synthetic Communications, 2011, vol. 41, # 2, p. 170 - 176 [5] Journal of Organic Chemistry, 1995, vol. 60, # 11, p. 3266 - 3267 [6] Synthetic Communications, 1998, vol. 28, # 2, p. 367 - 375 [7] Synthesis, 1999, # 1, p. 49 - 50 [8] RSC Advances, 2013, vol. 3, # 27, p. 10680 - 10686 [9] Tetrahedron, 1997, vol. 53, # 23, p. 7889 - 7896 [10] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 5, p. 607 - 610 [11] Bulletin of the Chemical Society of Japan, 2008, vol. 81, # 1, p. 160 - 162 [12] Phosphorus, Sulfur and Silicon and the Related Elements, 2013, vol. 188, # 9, p. 1236 - 1243 [13] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1997, vol. 36, # 5, p. 438 - 441 [14] Synthetic Communications, 1998, vol. 28, # 7, p. 1179 - 1187 [15] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2000, vol. 39, # 11, p. 863 - 866 [16] Phosphorus, Sulfur and Silicon and the Related Elements, 2004, vol. 179, # 11, p. 2315 - 2321 [17] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 7, p. 1513 - 1519 [18] RSC Advances, 2014, vol. 4, # 69, p. 36702 - 36707 [19] Organic Preparations and Procedures International, 1995, vol. 27, # 2, p. 216 - 219 [20] Synlett, 2002, # 2, p. 346 - 348 [21] Advanced Synthesis and Catalysis, 2015, vol. 357, # 10, p. 2180 - 2186 [22] Bulletin of the Chemical Society of Japan, 1992, vol. 65, # 4, p. 1131 - 1134 [23] Bulletin of the Chemical Society of Japan, 1998, vol. 71, # 7, p. 1649 - 1653 [24] Phosphorus, Sulfur and Silicon and the Related Elements, 2004, vol. 179, # 11, p. 2177 - 2182 [25] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2013, vol. 43, # 3, p. 264 - 272 [26] Catalysis Communications, 2018, vol. 114, p. 75 - 78 [27] Phosphorus, Sulfur and Silicon and the Related Elements, 2004, vol. 179, # 9, p. 1777 - 1781 [28] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 3, p. 473 - 479 [29] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 5, p. 625 - 627 [30] Research on Chemical Intermediates, 2017, vol. 43, # 3, p. 1609 - 1618 [31] Phosphorus, Sulfur and Silicon and the Related Elements, 2005, vol. 180, # 1, p. 117 - 123 [32] Organometallics, 2011, vol. 30, # 15, p. 4136 - 4143 [33] Yakugaku Kenkyu, 1959, vol. 31, p. 125,131 [34] Chem.Abstr., 1960, p. 11018 [35] Tetrahedron Letters, 2005, vol. 46, # 15, p. 2683 - 2686 [36] Tetrahedron, 2002, vol. 58, # 25, p. 5179 - 5184 [37] Chemical Communications, 2008, # 42, p. 5301 - 5303 [38] Organometallics, 2010, vol. 29, # 20, p. 4459 - 4463 [39] Green Chemistry, 2017, vol. 19, # 17, p. 4061 - 4066
