54608-52-5 2-肼基吡嗪

运输信息：常温运输。危险描述：非危险化学品，海关编码:29339900

化学合成

化学合成

路线1：2-肼基吡嗪的合成

• 步骤：将2-氯吡嗪（2.0g，17.5mmol）滴加到35％的水合肼水溶液（25.8g，97.8mmol）中，控制添加速率使反应温度不超过65℃；加完后加热至65℃，搅拌过夜；冷却至室温后蒸发溶剂，得到黄色粉末状标题化合物（1.5g）。
• 条件：以水为溶剂，反应温度63-65℃。
• 收率：75％。
• 表征：MS（ESI）计算值：C₄H₆N₄：110.1；实测值：111.4 [M+H]；¹H NMR（400MHz，CD₃OD）δ8.10（d，J=1.6Hz，1H），8.00（dd，J=3.2,1.6Hz，1H），7.73（d，J=3.2Hz，1H）。
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