四-(4-溴苯)乙烯为烯烃类有机物，可用作有机合成中间体。制备方法包括：(1)回流：在250mL双口烧瓶中加入四苯乙烯，注入溴水，搅拌并点板跟踪；(2)点板：用THF稀释反应混合物，石油醚-二氯甲烷(20∶1)作展开剂；(3)除溴：改装回流装置，加甲苯除溴蒸气；(4)浓缩：旋蒸至20mL；(5)色谱分离：石油醚-二氯甲烷(20∶1)作展开剂分离；(6)旋蒸：收集组分旋蒸得白色固体；(7)烘干：70℃烘干24h。反应物物料比1∶10、反应时间16h时产率最高。
有机合成中间体
合成路线 1（1. 合成：61326-44-1）
- 步骤：将75mmol（25G）1,1,2,2-四苯基乙烯置于干燥器架上的表玻璃中，将585mmol（30ml）溴化物液体倒入干燥器底部，用小孔封闭干燥器释放HBr，7天后收集黄色固体，用二氯甲烷/甲醇（2：1）重结晶得白色晶体。
- 条件：for 168 h（注：此处原文献条件可能存在笔误，实验步骤中反应时间为7天）；
- 收率：37g，76％。
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合成路线 2（2. 合成：61326-44-1）
- 步骤：在0℃下，氩气氛围中向粉末锌（2.15g，33mmol）的无水THF（40mL）悬浮液中滴加氯化钛（IV）（1.81mL，16.5mmol），混合物回流4小时后冷却至室温；加入（4-溴苯基）苯基甲酮（980mg，4.12mmol）和4,4'-二甲氧基二苯甲酮（1.0g，4.12mmol）的THF（70mL）溶液，加热回流5小时；冷却后用10％K₂CO₃水溶液（100mL）淬灭，真空过滤除去不溶物，水层用CH₂Cl₂（3×50mL）萃取，合并有机层用水（20mL）洗涤，Na₂SO₄干燥，减压除溶剂，柱色谱（硅胶/乙酸乙酯：石油醚1：5）纯化得浅黄色固体。
- 条件：With titanium tetrachloride; zinc In tetrahydrofuran; Reflux; Inert atmosphere；
- 收率：776mg，40％。
- 参考文献：[1] Dalton Transactions, 2007, # 15, p. 1477 - 1480；[2] Journal of Materials Chemistry C, 2017, vol. 5, # 44, p. 11565 - 11572；[3] Tetrahedron Letters, 2012, vol. 53, # 50, p. 6838 - 6842；[4] Patent: CN104557552, 2016, B. Location in patent: Paragraph 0051-0054；[5] Chemistry - A European Journal, 2016, vol. 22, # 45, p. 16028 - 16031；[6] Journal of Organic Chemistry, 2002, vol. 67, # 7, p. 2003 - 2012；[7] Journal of Materials Chemistry C, 2014, vol. 2, # 26, p. 5155 - 5160；[8] Chemistry - A European Journal, 2017, vol. 23, # 3, p. 644 - 651；[9] Chemistry - An Asian Journal, 2016, vol. 11, # 20, p. 2932 - 2937；[10] Patent: CN107188801, 2017, A. Location in patent: Paragraph 0046-0048; 0057；[11] Patent: CN105037179, 2017, B. Location in patent: Paragraph 0046-0048; 0055-0057; 0065-0067; 0075-0077
