2,4-二氨基苯酚作为重要中间体,广泛应用于医药、农药、染料等领域,具体用途需结合下游产品进一步确定。
医药; 农药; 染料
合成路线 1(1. 合成:95-86-3)
- 产率:96.16%
- 合成条件:Stage #1: With palladium on activated charcoal In methanol at 20℃; for 0.08 h; Autoclave; Inert atmosphere Stage #2: With hydrogen In methanol at 65℃; for 1.50 h; Autoclave
- 实验步骤:在1000ml高压釜中,依次加入100g 2,4-二硝基苯酚,405ml甲醇和6g Pd / C催化剂,将混合物在室温下搅拌5分钟,然后用氮气置换。同时,观察高压釜是否泄漏,升高温度,打开氢气入口阀门,反应温度为65°C,高压釜中的压力保持在0.48 MPa,持续1 h。氢气调节进口阀以使高压釜中的压力保持在0.85MPa 0.5小时,温度降至40℃,更换氮气3次,过滤排出物,回收Pd / C催化剂,并且滤液用氮气保护,目标产物为64.8g,收率为96.16%,纯度为99.2%。
- 参考文献:
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