7460-82-4 二乙二醇双对甲苯磺酸酯

运输方式：冰袋运输。危险性质：非危险化学品。海关编码2909.30.6000，存储类别11 - 可燃固体。WGK Germany:3，危险标志GHS07。危险性类别：眼部刺激类别2、经皮刺激类别2、特异性靶器官毒性-一次接触类别3。危险性描述：H315（造成皮肤刺激）、H319（造成严重眼刺激）、H335（可能造成呼吸道刺激）。信号词：Warning。防范说明：P261（避免吸入粉尘/烟雾）、P305+P351+P338（如进入眼睛，立即用大量水冲洗并寻求医疗建议）。

作为有机合成中间体，用于相关有机化学反应中构建特定官能团或分子骨架。

有机合成中间体

路线1：

• 步骤: 将二乙二醇溶于水，加入氢氧化钠搅拌至澄清；冷却至0℃，滴加4-甲苯磺酰氯的四氢呋喃溶液，0℃搅拌1小时；反应后用乙酸乙酯和水稀释，分离有机相，干燥、蒸发溶剂，经Biotage Isolera One纯化（二氯甲烷/甲醇梯度）得产物。
• 条件: 氢氧化钠水溶液，室温搅拌至澄清；0℃滴加反应物，0℃搅拌1小时；乙酸乙酯/水稀释，Biotage Isolera One纯化（HP-Sil SNAP柱，二氯甲烷/甲醇梯度100/0→100/0）。
• 收率: 47%。
• 参考文献: [1] Organic Letters, 2002, vol. 4, #14, p.2329-2332；[2] Molecules, 2011, vol.16, #6, p.4748-4763；[3] Drug Design, Development and Therapy, 2018, vol.12, p.987-995；[4] Patent: WO2015/110263, 2015, A1（Page/Page column 239; 240）。

路线2：

• 步骤: 将低聚乙二醇（二乙二醇）和对甲苯磺酰氯溶解于二氯甲烷，冷却至0℃；加入研磨的氢氧化钾，0-10℃搅拌3小时；TLC监测反应；升温至室温后，氯仿稀释，水（3×1:1）萃取，收集氯仿萃取物，硫酸镁干燥，减压蒸发溶剂。
• 条件: 二氯甲烷溶剂，0-10℃反应3小时；TLC（UV检测）监控；氯仿/水萃取体系。
• 收率: 99%。
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