化学合成
化学合成
合成路线 1（1. 合成：21461-84-7）
产率：91.6%
合成条件：With hydrogenchloride; sodium nitrite In water at -5 - 20℃; Inert atmosphere
实验步骤：向L-谷氨酸（10.07g，0.068mol，JK CHEMICA）在20ml锥形溶液中的溶液中。 在-5℃下，向HCl和40mL H₂O中缓慢加入NaNO₂（7.0g，0.102mol，汕头西龙化学工厂）在H₂O（20mL）中的溶液。 将混合物在室温下继续搅拌12小时。 将反应混合物在低于50℃下真空蒸发，得到黄色油状物，将其溶解在EtOAc中。 过滤形成的固体并用EtOAc洗涤。 合并滤液和洗涤溶液，用Na₂SO₄干燥。 将溶剂真空浓缩，得到（S）-四氢-5-氧代呋喃-2-羧酸，为浅黄色油状物（8.1g，91.6％），MS（ESI，阳离子）m/z：130.9（M + 1）; ¹H NMR（400MHz，CDCl₃）：δ2.27-2.41（m，1H），2.44-2.65（m，3H），5.09（m，1H），9.12-9.55（m，1H）。
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