5000-66-8 2-溴-2'-氯苯乙酮

运输信息：冰袋运输。危险描述：危险品运输编号UN 2922 8/PG 2，危险等级8，包装类别II，海关编码29143900，存储类别6.1A - 可燃，急性毒性物质（类别1和类别2）剧毒的危险物质，危险性类别皮肤腐蚀类别1B，Hazard Note:Corrosive/Lachrymatory/Keep Cold，WGK Germany:3。

化学合成

化学合成

路线1：氧化溴化法

• 步骤：搅拌1.2g苯乙酮1a（10mmol）和0.121g Cu(NO₃)₂·3H₂O（0.5mmol）的混合物，连接氧气球（约0.5-1L）；滴加8mol/L氢溴酸水溶液（1.5mL，12mmol）；70℃搅拌3.5h（TLC或GC监测）；反应完成后用CH₂Cl₂萃取，有机相依次用5％亚硫酸钠、饱和碳酸氢钠溶液、水洗涤，无水硫酸镁干燥；真空除溶剂，残余物经柱色谱（硅胶，石油醚/二氯甲烷3：1）纯化得产物α-溴苯乙酮（2a）
• 条件：70℃，3.5h，氧气氛围
• 产率：91％
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