4-氟苯甲酰甲醛水合物为醛类衍生物,可用作医药合成中间体;若吸入,应将患者移到新鲜空气处;若皮肤接触,应脱去污染的衣着,用肥皂水和清水彻底冲洗皮肤,如有不适感,就医。
医药
路线1:以4-氟苯乙酮为原料合成4-氟代苯甲酰甲醛
- 步骤:将二氧化硒(6.70 g,61.0 mmol)加入到含有4-氟苯乙酮(8.43 g,61.0 mmol)的二恶烷(100 mL)和水(3 mL)的混合溶液中;将混合物在55℃加热至二氧化硒完全溶解,随后回流5-6小时;TLC监测反应完成后,过滤混合物,滤液真空浓缩得粘性油状物;向油状物中加入水(50 mL),搅拌12小时,收集固体,用水洗涤并真空干燥,得到4-氟苯基乙二醛(6.60 g)。
- 条件:55℃加热至二氧化硒溶解,随后回流5-6小时;溶剂为二恶烷和水(体积比约33:1)。
- 收率:85%。
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