3-氯-3-甲基-1-丁炔是重要的化工有机中间体，可用于农药、杀菌剂、除草剂等多种化工领域。制备方法：将1000 kg 3-甲基丁炔-3-醇投入到275 kg的36%盐酸中（氯化釜），加入氯化亚铜10kg，然后将1200 kg间苯二甲酸与1440 kg三氯甲基苯投入到酰氯化釜中并升温至70 ~85 ℃，投入1.5kg三氯化铁，保温3小时后滴加1440 kg三氯甲基苯，3小时滴加完毕。期间，冷媒设置温度为-20 ℃，盐酸洗涤塔中盐酸为外购浓盐酸，浓度为30%，洗涤过程洗涤液温度为40 ~ 45 ℃。盐酸洗涤液中回收的苯甲酸纯度为97.32%，最后得到的3-氯-3-甲基丁炔的纯度为94.57%，收率96.28%。
农药; 杀菌剂; 除草剂
合成路线 1（1. 合成：1111-97-3）
- 产率：95%
- 条件：With hydrogenchloride; sulfuric acid; zinc(II) chloride In water at 0 - 5℃; for 2 h;
- 步骤：打开氯化反应器并返回冷冻阀。将反应容器冷却至10℃，依次加入盐酸、氯化锌和聚乙二醇600；将3-羟基-3-甲基丁烯和硫酸滴加到反应容器中，加完后保持0至5℃反应2小时。反应完成后转移到洗涤釜中洗涤，搅拌静置，分离水层后转移到泵送釜，抽滤、干燥得到3-氯-3-甲基丁烯（产率95％，纯度99％）。
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合成路线 2（2. 合成：1111-97-3）
- 产率：未提供
- 条件：未提供
- 步骤：未提供
- 参考文献：[1] Journal of the American Chemical Society, 1951, vol. 73, p. 4013
合成路线 3（3. 合成：1111-97-3）
- 产率：未提供
- 条件：未提供
- 步骤：未提供
- 参考文献：[1] Journal of the American Chemical Society, 1960, vol. 82, p. 4094 - 4097
