5-甲氧基-异苯并呋喃-1,3-二酮是典型的异苯并呋喃酮类化合物，可用作医药中间体；以4-甲氧基邻苯二甲酸为起始物料，经分子内脱水关环反应制备目标化合物。
医药中间体
路线1：
- 步骤: 将乙酸酐（40ml）加入到4-甲氧基邻苯二甲酸（30.8g，0.16mol）的无水四氢呋喃（150ml）混合物中，搅拌并保持回流4小时；冷却至室温后，真空除去溶剂，得到4-甲氧基邻苯二甲酸酐（27.8g，99％），为灰白色固体。
- 条件: With acetic anhydride In tetrahydrofuran for 4 h; Heating / reflux
- 产率: 99%
- 参考文献: [1] Patent: WO2008/44029, 2008, A1. Location in patent: Page/Page column 204 [2] Patent: WO2008/44041, 2008, A1. Location in patent: Page/Page column 225-226 [3] Patent: WO2008/44045, 2008, A1. Location in patent: Page/Page column 277-278 [4] Patent: WO2008/44054, 2008, A2. Location in patent: Page/Page column 122 [5] Patent: US2010/152184, 2010, A1. Location in patent: Page/Page column 72; 73 [6] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 5956 - 5969 [7] RSC Advances, 2016, vol. 6, # 52, p. 46170 - 46185 [8] Journal of Natural Products, 2018, vol. 81, # 6, p. 1460 - 1467 [9] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5701 - 5704 [10] Patent: WO2009/54653, 2009, A2. Location in patent: Page/Page column 25 [11] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1628 - 1631 [12] Patent: WO2011/68821, 2011, A1. Location in patent: Page/Page column 108 [13] Chemische Berichte, 1883, vol. 16, p. 1964 [14] Journal of the Chemical Society, 1909, vol. 95, p. 1883 [15] Helvetica Chimica Acta, 1931, vol. 14, p. 513 [16] Chemische Berichte, 1938, vol. 71, p. 907,910 [17] Chemische Berichte, 1988, vol. 121, p. 243 - 252 [18] Journal of the American Chemical Society, 2014, vol. 136, # 17, p. 6239 - 6242 [19] Chemistry - A European Journal, 2016, vol. 22, # 34, p. 11997 - 12001 [20] Molecules, 2017, vol. 22, # 2
