20249-16-5 3-氧代环丁烷甲腈

运输信息：冰袋运输。危险描述：非危险化学品，海关编码2926907090。

化学合成；3-氧代环丁烷甲腈是一种有机化合物，常用作医药中间体，可由3-亚甲基环丁烷甲腈氧化制备得到，可用的氧化剂为高碘酸钠和臭氧。

医药

路线1：

• 原料：3-亚甲基环丁烷甲腈（30g，370mmol）、偏高碘酸钠（284g，1.32mol）、三氯化钌一水合物（1.5g，7.23mmol，2.2mol%）
• 溶剂：DCM-MeCN-水（645mL:645mL:945mL）
• 步骤：在5℃下，将偏高碘酸钠分小批（30-45分钟内）加入到3-亚甲基环丁烷甲腈和三氯化钌一水合物的混合溶剂中；反应混合物在室温下剧烈搅拌；分离有机相，水相用DCM（3×1500mL）萃取；合并的有机萃取物通过快速硅胶小垫过滤，硅胶垫用2000mL DCM洗涤；滤液用MgSO₄干燥，过滤并减压浓缩，得到产物。
• 条件：5-20℃（反应温度）
• 收率：100%
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