- 英文名称
- Sodium taurochenodeoxycholate
- 分子式
- C26H44NNaO6S
- 分子量
- 521.69
- 中文别名
- 牛磺去氧鹅胆酸钠; 熊去氧胆酸杂质15; 牛磺鹅脱氧胆酸钠; 牛磺鹅脱氧胆酸钠盐; TAUROCHENODEOXYCHOLIC ACID SODIUM SALT; 2-([3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid sodium salt; 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt; Taurochenodeoxy; taurochenodeoxycholic acid soduim salt; 2-([3-ALPHA,7-ALPHA-DIHYDROXY-24-OXO-5-BETA-CHOLAN-24-YL]AMINO)ETHANESULFONIC ACID SODIUM SALT; 5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA-DIOL N-(2-SULPHOETHYL)-AMIDE SODIUM SALT; 5BETA-CHOLANIC ACID-3ALPHA,7ALPHA-DIOL-24-N-(2-SULFOETHYL)-AMIDE SODIUM; 2-(((3α,5β,7α)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)ethanesulfonic acid monosodium salt; Ethanesulfonic acid, 2-[[(3α,5β,7α,8ξ)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1); Ethanesulfonic acid, 2-(((3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl)amino)-, monosodium salt; Sodium 2-{[(3α,5β,7α,8ξ)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate
- 用途
- - 生物活性
Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) 是动物胆汁酸的主要生物活性物质之一。Taurochenodeoxycholic acid 可诱导细胞凋亡 (apoptosis)，并具有明显的抗炎和免疫调节作用。
- 靶点
Human Endogenous Metabolite
- 体外研究
Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities.
- 体内研究
Taurochenodeoxycholic acid (0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2.
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation.
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.
- 生化研究；脂酶加速剂；阴离子去除剂，用于蛋白质的溶解；制备细菌培养基(肠道细菌培养与分离)
