- 英文名称
- 3,9-Bis((ethylthio)methyl)-K-252a
- 分子式
- C33H33N3O5S2
- 分子量
- 615.76
- 中文别名
- Cep 1347游离态; CEP-1347; Proxyfan oxalate; [9S-(9α,10β,12α)]-5,16-bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3'',2'',1''-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester; 3,9-Bis(etsm)-K-252a; Cep 1347; Cep1347; Kt 7515; Kt7515; KT-7515; KT-1575; (9S,10R,12R)-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
- 用途
- CEP-1347是JNK/SAPK通路的抑制剂，具有神经保护作用，能阻断MLK家族成员（MLK3、MLK2和MLK1等）诱导的JNK1活化，作为MDM4的抑制剂，可更有效地抑制表达野生型p53的胶质瘤细胞的生长。
